Mamdouh Muhammad Salem (Arabic: ممدوح سالم, May 7, 1918 – February 24, 1988) was an Egyptian politician, military, and the 39th Prime Minister of Egypt from April 16, 1975 to October 2, 1978.

He graduated from the Police College. Later he became director of Alexandria security and ranked major general. President Gamal Abdel Nasser chose him to be responsible for his personal security (1960 - 1967). Then he was appointed Governor of Assiut in 1967, Governor of Gharbia in 1970, then Governor of Alexandria in 1970, Minister of Interior in 1971, Deputy Prime Minister and Minister of Interior in 1972.

Sadat chose him as prime minister in 1975, during which parliamentary elections were held. In 1978 he was chosen as an assistant to the President of the Republic.

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