On 12 May 2011, van der Westhuizen's publicist announced that he had a muscle-related neural disease. It was believed to be a form of motor neurone disease. Doctors at the Cleveland Clinic in the United States[1] have since confirmed that he had motor neurone disease. They believed he had only a 20% chance of living for two to five years.[2]
On 6 February 2017, van der Westhuizen died at a hospital in Johannesburg, South Africa from complications of motor neurone disease, aged 45.[3]