She started her career as a Playboy model in 1993. She later became an actress, comedian, author and supposed autism activist who has no insight into what causes autism. In 2013 McCarthy hosted a show called The Jenny McCarthy Show for one season.
McCarthy married John Mallory Asher in 1999. The couple's son, Evan Joseph was born in 2002. In 2005, Evan was diagnosed with autism. the couple divorced in 2005. She lived withJim Carrey; the couple split in 2010. She married Donnie Wahlberg in 2014.