Irwin Fridovich

Irwin Fridovich
Irwin Fridovich in 1994
Born(1929-08-02)August 2, 1929
New York City, New York, U.S.
DiedNovember 2, 2019(2019-11-02) (aged 90)
Durham, North Carolina, U.S.
CitizenshipUnited States
Alma materCity College of New York (BS 1951), Duke University (PhD 1955)
Known forsuperoxide dismutase, oxygen free radicals
AwardsElliott Cresson Medal (1997)
Scientific career
FieldsBiochemistry
InstitutionsDuke University
Doctoral advisorPhilip Handler
Doctoral studentsJoe M. McCord, Hara P. Misra

Irwin Fridovich (August 2, 1929 – November 2, 2019)[1] was an American biochemist. He discovered the enzymatic activity of copper,zinc superoxide dismutase (SOD),[2][3]—to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct of normal oxygen metabolism.[4]

He spent the rest of his career studying the biochemical mechanisms.[5][6][7] Fridovich was also Professor Emeritus of Biochemistry at Duke University.

References

  1. ↑ "Duke Flags Lowered: Biochemist Irwin Fridovich Dies at Age 90".
  2. ↑ McCord JM, Fridovich I (1969). "Superoxide Dismutase, An Enzymic Function for Erythrocuprein (Hemocuprein)". Journal of Biological Chemistry. 244 (22): 6049–6055. doi:10.1016/S0021-9258(18)63504-5. PMID 5389100.
  3. ↑ Fridovich I (1998). "The trail to superoxide dismutase". Protein Science. 7 (12): 2688–2690. doi:10.1002/pro.5560071225. PMC 2143889. PMID 9865966.
  4. ↑ Bannister WH, Bannister JV (1988). "Isolation and characterization of superoxide dismutase: a personal history and tribute to Joe McCord and Irwin Fridovich". Free Radical Biology and Medicine. 5 (5–6): 371–6. doi:10.1016/0891-5849(88)90110-4. PMID 2855737.
  5. ↑ Fridovich I (1978). "The biology of oxygen radicals". Science. 201 (4359): 875–880. Bibcode:1978Sci...201..875F. doi:10.1126/science.210504. PMID 210504.
  6. ↑ Fridovich I (1995). "Superoxide radical and superoxide dismutases". Annual Review of Biochemistry. 64: 97–112. doi:10.1146/annurev.bi.64.070195.000525. PMID 7574505.
  7. ↑ Kresge N, Simoni RD, Hill RL (2006). "Forty Years of Superoxide Dismutase Research: the Work of Irwin Fridovich (JBC Classics: Enzymology)". The Journal of Biological Chemistry. 281 (22): e17. doi:10.1016/S0021-9258(20)56010-9. Retrieved July 3, 2011.{{cite journal}}: CS1 maint: multiple names: authors list (link)