The Indian massacre of 1622 (also known as the Jamestown Massacre) was an event where around 347[1] people were killed in the Virginia Colony of North America on Good Friday, March 22, 1622. The number killed, 347, was almost one-third of the English population of Jamestown. They were killed by a number of surprise attacks by the Powhatan Confederacy (a Native American tribe), who were ruled by Chief Opechancanough.