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Guna de Wargandí is an indigenous region in Pinogana District, Darién Province, Panama. In 2010, 1,914 people lived there. Its area is 775 km². It was created on 25 July 2000. The largest ethnic group is Guna.

The comarca is divided into three communities instead of districts: Mortí, Nurra and Wala. The capital is Nurra.

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