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Duloxetine

Duloxetine is a medication. It is sold under the brand name Cymbalta, among others.

Uses

Duloxetine's chemical structure

Duloxetine is used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, nerve pain, and other types of chronic pain.[1][2][3] It is taken by mouth.[4]

Function

Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI).[2] This means the medication increases the activity of serotonin and norepinephrine in the brain.[1][2] However, the precise mechanism for duloxetine's antidepressant and anti-anxiety effects is not known.

References

  1. ↑ 1.0 1.1 "Duloxetine (oral route) - Side effects & dosage". Mayo Clinic. Retrieved 2025-09-13.
  2. ↑ 2.0 2.1 2.2 "Duloxetine Delayed-Release Capsules: Uses & Side Effects". Cleveland Clinic. Retrieved 2025-09-13.
  3. ↑ "Medications for OCD". International OCD Foundation. Archived from the original on 27 January 2024. Retrieved 25 February 2024.
  4. ↑ "Duloxetine". Monograph. The American Society of Health-System Pharmacists. Archived from the original on 26 November 2018. Retrieved 13 September 2025.

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