Calhoun County
County
Calhoun County Courthouse
Motto:  "In the Heart of South Carolina"
Location within the U.S. state of South Carolina
South Carolina's location within the U.S.
Coordinates: 33°40′29″N 80°46′49″W / 33.67478°N 80.780347°W / 33.67478; -80.780347
Country	United States
State	South Carolina
Founded	1908
Named for	John C. Calhoun
Seat	St. Matthews
Largest community	St. Matthews
Area
• Total	392.48 sq mi (1,016.5 km2)
• Land	381.15 sq mi (987.2 km2)
• Water	11.33 sq mi (29.3 km2)  2.89%
Population  (2020)
• Total	14,119
• Density	37.04/sq mi (14.30/km2)
Time zone	UTC−5 (Eastern)
• Summer (DST)	UTC−4 (EDT)
Congressional district	6th
Website	calhouncounty.sc.gov

Calhoun County is a county in South Carolina. The population was 14,119 at the 2020 census.^[1] It is the third least populated county in South Carolina. The county seat is St. Matthews.

Calhoun County is part of the Columbia, SC Metropolitan Statistical Area.

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