The 33rd Annual Annie Awards were held on 4 February 2006 at the Alex Theatre in Glendale, California. They were hosted by Tom Kenny.

Winners are highlighted in boldface.

• Chicken Little
• Corpse Bride
• Howl's Moving Castle
• Madagascar (film)
• Wallace & Gromit: The Curse of the Were-Rabbit

• Bionicle 3: Web of Shadows
• Kronk's New Groove
• Lilo & Stitch 2: Stitch Has A Glitch
• Tarzan II
• The Batman vs Dracula

• The Fan and the Flower
• Life in Transition
• Milch
• Moongirl
• The Moon and the Son: An Imagined Conversation

• ConocoPhillips - "1975"
• They Might Be Giants - "Bastard Wants to Hit Me"
• Coke - "Futbol"
• GE - "Tower"
• United Airlines - "Mr. Pants"

• Avatar: The Last Airbender
• Foster's Home for Imaginary Friends
• My Life As a Teenage Robot
• Star Wars: Clone Wars
• The Batman

• Psychonauts
• Resident Evil 4
• SpongeBob SquarePants: Lights, Camera, Pants!
• Tak: The Great Juju Challenge
• Ultimate Spider-Man