2043 (MMXLIII) will be a common year starting on Thursday of the Gregorian calendar, the 2043rd year of the Common Era (CE) and Anno Domini (AD) designations, the 43rd year of the 3rd millennium, the 43rd year of the 21st century, and the 4th year of the 2040s decade.

• January 1 – Books, movies, and other works published in 1947 will enter the public domain in the United States.

• March 20 - 100th anniversary of the Droopy.

• May 8 - 100th anniversary of the Red Hot Riding Hood.
• May 15 - 100th anniversary of the ABC.

• June 11 - 50th anniversary of the Jurassic Park.

100th anniversary of the Revue Studios.

2043 will see the close of 6000 years of human history, according to the count of years in the Hebrew Old Testament. This may be readily computed by placing the construction of Solomon's Temple (1 Kings 6:1) at 966 BC, a widely accepted date based on the work of Edwin Thiele in the mid 20th century. From 966 BC count back 2992 years to the first man, as given in the Old Testament record. (1656 Adam to the Flood, 427 to Abraham, 430 to the Exodus, 479 to 1 Kings 6:1.) This places the first man at 3958 BC. 6000 years forward takes one to 2043 AD.

• 2043 marks the first contact between humans and the Centaurians in the computer game Alien Legacy.
• According to the Acecombat universe, war breaks out between Neucom Inc. and General Resource Ltd. The Universal Peace Enforcement Organization is sent to settle the conflict. The war lasts until 2044.
• The video game Rise of the Robots takes place in November.
• The movie The Postman (1997) concludes.
• The 2010 movie The Book of Eli is set.