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Uracil/timin dehidrogenaza
Identifikatori
EC broj	1.17.99.4
CAS broj	9029-00-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Uracil/timin dehidrogenaza (EC 1.17.99.4, uracil oksidaza, uracil-timin oksidaza) je enzim sa sistematskim imenom uracil:akceptor oksidoreduktaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) uracil + H₂O + akceptor

\rightleftharpoons

barbiturat + redukovani akceptor

(2) timin + H₂O + akceptor

\rightleftharpoons

5-metilbarbiturat + redukovani akceptor

Ovaj enzim formira deo oksidativnog puta degradacije pirimidina kod nekih mikroorganizama, zajedno sa EC 3.5.2.1 (barbiturazom) i EC 3.5.1.95 (N-malonilurejskom hidrolazom).

Reference

↑ Hayaishi, O. and Kornberg, A. (1952). „Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes”. J. Biol. Chem. 197: 717-723. PMID 12981104.
↑ Wang, T.P. and Lampen, J.O. (1952). „Metabolism of pyrimidines by a soil bacterium”. J. Biol. Chem. 194: 775-783. PMID 14927671.
↑ Wang, T.P. and Lampen, J.O. (1952). „Uracil oxidase and the isolation of barbituric acid from uracil oxidation”. J. Biol. Chem. 194: 785-791. PMID 14927672.
↑ Lara, F.J.S. (1952). „On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations”. J. Bacteriol. 64: 279-285. PMID 14955523.
↑ Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222-226. PMID 11485332.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Uracil/thymine+dehydrogenase

[1] Hayaishi, O. and Kornberg, A. (1952). „Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes”. J. Biol. Chem. 197: 717-723. PMID 12981104.

[2] Wang, T.P. and Lampen, J.O. (1952). „Metabolism of pyrimidines by a soil bacterium”. J. Biol. Chem. 194: 775-783. PMID 14927671.

[3] Wang, T.P. and Lampen, J.O. (1952). „Uracil oxidase and the isolation of barbituric acid from uracil oxidation”. J. Biol. Chem. 194: 785-791. PMID 14927672.

[4] Lara, F.J.S. (1952). „On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations”. J. Bacteriol. 64: 279-285. PMID 14955523.

[5] Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222-226. PMID 11485332.

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