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Undekaprenilna difosfataza
Identifikatori
EC broj	3.6.1.27
CAS broj	9077-80-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Undekaprenilna difosfataza (EC 3.6.1.27, C⁵⁵-izoprenilna difosfataza, C⁵⁵-izoprenilna pirofosfataza, izoprenilna pirofosfataza, undekaprenil pirofosfatna fosfataza, undekaprenil pirofosfatna pirofosfataza, UPP fosfataza, Und-PP pirofosfataza, UppP, BacA, undekaprenil-difosfatna fosfohidrolaza, undekaprenil-difosfataza) je enzim sa sistematskim imenom ditrans,oktacis-undekaprenil-difosfat fosfohidrolaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ditrans,oktacis-undekaprenil difosfat + H₂O

\rightleftharpoons

ditrans,oktacis-undekaprenil fosfat + fosfat

Ovaj enzim je izolovan iz bakterija Micrococcus lysodeikticus, Escherichia coli i Bacillus subtilis.

Reference

↑ Goldman, R. and Strominger, J.L. (1972). „Purification and properties of C₅₅-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus”. J. Biol. Chem. 247: 5116-5122. PMID 4341539.
↑ El Ghachi, M., Bouhss, A., Blanot, D. and Mengin-Lecreulx, D. (2004). „The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity”. J. Biol. Chem. 279: 30106-30113. PMID 15138271.
↑ El Ghachi, M., Derbise, A., Bouhss, A. and Mengin-Lecreulx, D. (2005). „Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli”. J. Biol. Chem. 280: 18689-18695. PMID 15778224.
↑ Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M. and Denizot, F. (2005). „BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance”. J. Biol. Chem. 280: 28852-28857. PMID 15946938.
↑ Tatar, L.D., Marolda, C.L., Polischuk, A.N., van Leeuwen, D. and Valvano, M.A. (2007). „An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling”. Microbiology 153: 2518-2529. PMID 17660416.
↑ Touze, T., Blanot, D. and Mengin-Lecreulx, D. (2008). „Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase”. J. Biol. Chem. 283: 16573-16583. PMID 18411271.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Undecaprenyl-diphosphate+phosphatase

[1] Goldman, R. and Strominger, J.L. (1972). „Purification and properties of C₅₅-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus”. J. Biol. Chem. 247: 5116-5122. PMID 4341539.

[2] El Ghachi, M., Bouhss, A., Blanot, D. and Mengin-Lecreulx, D. (2004). „The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity”. J. Biol. Chem. 279: 30106-30113. PMID 15138271.

[3] El Ghachi, M., Derbise, A., Bouhss, A. and Mengin-Lecreulx, D. (2005). „Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli”. J. Biol. Chem. 280: 18689-18695. PMID 15778224.

[4] Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M. and Denizot, F. (2005). „BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance”. J. Biol. Chem. 280: 28852-28857. PMID 15946938.

[5] Tatar, L.D., Marolda, C.L., Polischuk, A.N., van Leeuwen, D. and Valvano, M.A. (2007). „An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling”. Microbiology 153: 2518-2529. PMID 17660416.

[6] Touze, T., Blanot, D. and Mengin-Lecreulx, D. (2008). „Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase”. J. Biol. Chem. 283: 16573-16583. PMID 18411271.

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