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Ubikvitin-proteinska ligaza
Identifikatori
EC broj	6.3.2.19
CAS broj	74812-49-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Ubikvitin-proteinska ligaza (EC 6.3.2.19, ubikvitin-aktivirajući enzim) je enzim sa sistematskim imenom ubikvitin:protein-lizin N-ligaza (formira AMP).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + ubikvitin + protein lizin

\rightleftharpoons

AMP + difosfat + protein N-ubikvitilizin

Ubikvitin je vezan za ovaj protein peptidnom vezom između C-terminalnog glicina ubikvitina i epsilon-amino grupa lizinskih ostataka proteina.

Reference

↑ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982). „Covalent affinity purification of ubiquitin-activating enzyme”. J. Biol. Chem. 257: 2537-2542. PMID 6277904.
↑ Haas, A.L. and Rose, I.A. (1982). „The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis”. J. Biol. Chem. 257: 10329-10337. PMID 6286650.
↑ Haas, A.L., Warms, J.V.B., Hershko, A. and Rose, I.A. (1982). „Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation”. J. Biol. Chem. 257: 2543-2548. PMID 6277905.
↑ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase system”. J. Biol. Chem. 261: 11992-11999. PMID 3017957.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Ubiquitin-protein+ligase

[1] Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982). „Covalent affinity purification of ubiquitin-activating enzyme”. J. Biol. Chem. 257: 2537-2542. PMID 6277904.

[2] Haas, A.L. and Rose, I.A. (1982). „The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis”. J. Biol. Chem. 257: 10329-10337. PMID 6286650.

[3] Haas, A.L., Warms, J.V.B., Hershko, A. and Rose, I.A. (1982). „Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation”. J. Biol. Chem. 257: 2543-2548. PMID 6277905.

[4] Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase system”. J. Biol. Chem. 261: 11992-11999. PMID 3017957.

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