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Ubikvitin-kalmodulinska ligaza
Identifikatori
EC broj	6.3.2.21
CAS broj	119632-60-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Ubikvitin-kalmodulinska ligaza (EC 6.3.2.21, ubikvitil-kalmodulinska sintaza, ubikvitin-kalmodulinska sintetaza, ubikvitil-kalmodulinska sintetaza, uCaM-sintetaza) je enzim sa sistematskim imenom kalmodulin:ubikvitin ligaza (formira AMP).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

n ATP + kalmodulin + n ubikvitin

\rightleftharpoons

n AMP + n difosfat + (ubikvitin)N-kalmodulin

Ovaj enzim je specifičan za Ca²⁺-kalmodulin kod kičmenjaka.

Reference

↑ Jennissen, H.P. and Laub, M. (1988). „Ubiquitin-calmodulin conjugating activity from cardiac muscle”. Biol. Chem. Hoppe-Seyler 369: 1325-1330. PMID 2853950.
↑ Ziegenhagen, R. and Jennissen, H.P. (1988). „Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase”. Biol. Chem. Hoppe-Seyler 369: 1317-1324. PMID 2853949.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Ubiquitin---calmodulin+ligase

[1] Jennissen, H.P. and Laub, M. (1988). „Ubiquitin-calmodulin conjugating activity from cardiac muscle”. Biol. Chem. Hoppe-Seyler 369: 1325-1330. PMID 2853950.

[2] Ziegenhagen, R. and Jennissen, H.P. (1988). „Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase”. Biol. Chem. Hoppe-Seyler 369: 1317-1324. PMID 2853949.

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