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UDP-glucuronska kiselina dehidrogenaza
Identifikatori
EC broj	1.1.1.305
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

UDP-glucuronska kiselina dehidrogenaza (EC 1.1.1.305, UDP-GlcUA dekarboksilaza, ArnADH) je enzim sa sistematskim imenom UDP-glukuronat:NAD⁺ oksidoreduktaza (dekarboksilacija).^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-glukuronat + NAD⁺

\rightleftharpoons

UDP-beta-L-treo-pentapiranoz-4-uloza + CO₂ + NADH + H⁺

Ova dehidrogenaza je deo bifunkcionalnog enzima koji takođe izvodi reakciju EC 2.1.2.13, UDP-4-amino-4-dezoksi-L-arabinoza formiltransferaza.

Reference

↑ Breazeale, S.D., Ribeiro, A.A., McClerren, A.L. and Raetz, C.R.H. (2005). „A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose”. J. Biol. Chem. 280: 14154-14167. PMID 15695810.
↑ Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2004). „Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance”. Biochemistry 43: 13370-13379. PMID 15491143.
↑ Williams, G.J., Breazeale, S.D., Raetz, C.R.H. and Naismith, J.H. (2005). „Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis”. J. Biol. Chem. 280: 23000-23008. PMID 15809294.
↑ Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2005). „Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance”. Structure 13: 929-942. PMID 15939024.
↑ Yan, A., Guan, Z. and Raetz, C.R.H. (2007). „An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli”. J. Biol. Chem. 282: 36077-36089. PMID 17928292.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH UDP-glucuronic+acid+dehydrogenase+(UDP-4-keto-hexauronic+acid+decarboxylating)

[1] Breazeale, S.D., Ribeiro, A.A., McClerren, A.L. and Raetz, C.R.H. (2005). „A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-amino-4-deoxy-L-arabinose. Identification and function of UDP-4-deoxy-4-formamido-L-arabinose”. J. Biol. Chem. 280: 14154-14167. PMID 15695810.

[2] Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2004). „Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance”. Biochemistry 43: 13370-13379. PMID 15491143.

[3] Williams, G.J., Breazeale, S.D., Raetz, C.R.H. and Naismith, J.H. (2005). „Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis”. J. Biol. Chem. 280: 23000-23008. PMID 15809294.

[4] Gatzeva-Topalova, P.Z., May, A.P. and Sousa, M.C. (2005). „Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance”. Structure 13: 929-942. PMID 15939024.

[5] Yan, A., Guan, Z. and Raetz, C.R.H. (2007). „An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli”. J. Biol. Chem. 282: 36077-36089. PMID 17928292.

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