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UDP-N-acetilglukozamin—lizozomalni-enzim N-acetilglukozaminfosfotransferaza
Identifikatori
EC broj	2.7.8.17
CAS broj	84012-69-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

UDP-N-acetilglukozamin—lizozomalni-enzim N-acetilglukozaminfosfotransferaza (EC 2.7.8.17, N-acetilglukozaminilfosfotransferaza, UDP-N-acetilglukozamin:lizozomalni enzim N-acetilglukozamin-1-fosfotransferaza, UDP-GlcNAc:glikoprotein N-acetilglukozamin-1-fosfotransferaza, uridin difosfoacetilglukozamin-lizozomalni enzim prekurzor acetilglukozamin-1-fosfotransferaza, uridin difosfoacetilglukozamin-glikoprotein acetilglukozamin-1-fosfotransferaza, lizozomalni enzim prekurzor acetilglukozamin-1-fosfotransferaza, N-acetilglukozaminilna fosfotransferaza, UDP-acetilglukozamin:lizozomalni enzim N-acetilglukozamin-1-fosfotransferaza, UDP-GlcNAc:lizozomalni enzim N-acetilglukozamin-1-fosfotransferaza, UDP-N-acetilglukozamin:glikoprotein N-acetilglukozamin-1-fosfotransferaza, UDP-N-acetilglukozamin:glikoprotein N-acetilglukozaminil-1-fosfotransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:lizozomalni-enzim N-acetilglukozaminfosfotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + lizozomalni-enzim D-manoza

\rightleftharpoons

UMP + lizozomalni-enzim N-acetil-D-glukozaminil-fosfo-D-manoza

Neki drugi glikoproteini sa visokim sadržajem manoze mogu da budu akceptori.

Reference

↑ Reitman, M.L. and Kornfeld, S. (1981). „UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes”. J. Biol. Chem. 256: 4275-4281. PMID 6452459.
↑ Reitman, M.L. and Kornfeld, S. (1981). „Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes”. J. Biol. Chem. 256: 11977-11980. PMID 6457829.
↑ Waheed, A., Hasilik, A. and von Figura, K. (1982). „UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme”. J. Biol. Chem. 257: 12322-12331. PMID 6288715.
↑ Waheed, A., Pohlmann, R., Hasilik, A. and von Figura, K. (1981). „Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes”. J. Biol. Chem. 256: 4150-4152. PMID 6260788.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH UDP-N-acetylglucosamine---lysosomal-enzyme+N-acetylglucosaminephosphotransferase

[1] Reitman, M.L. and Kornfeld, S. (1981). „UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes”. J. Biol. Chem. 256: 4275-4281. PMID 6452459.

[2] Reitman, M.L. and Kornfeld, S. (1981). „Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes”. J. Biol. Chem. 256: 11977-11980. PMID 6457829.

[3] Waheed, A., Hasilik, A. and von Figura, K. (1982). „UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme”. J. Biol. Chem. 257: 12322-12331. PMID 6288715.

[4] Waheed, A., Pohlmann, R., Hasilik, A. and von Figura, K. (1981). „Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes”. J. Biol. Chem. 256: 4150-4152. PMID 6260788.

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