PROFILPELAJAR.COM

Transportujuća ATPaza polarnih aminokiselina
Identifikatori
EC broj	3.6.3.21
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Transportujuća ATPaza polarnih aminokiselina (EC 3.6.3.21, histidinska permeaza) je enzim sa sistematskim imenom ATP fosfohidrolaza (import polarne aminokiseline).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + H₂O + polar amino kiselinaout

\rightleftharpoons

ADP + fosfat + polar aminokiselina_in

Ova ATPaza ABC-tipa je karakteristična po prisustvu dva slična ATP-vezujuća domena.

Reference

↑ Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. (1995). „Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases”. Res. Microbiol. 146: 271-278. PMID 7569321.
↑ Saier, M.H., Jr. (1998). „Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya”. Adv. Microb. Physiol. 40: 81-136. PMID 9889977.
↑ Nikaido, K., Liu, P.Q. and Ferro-Luzzi Ames, G. (1997). „Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubilization, dimerization , and ATPase activity”. J. Biol. Chem. 272: 27745-27752. PMID 9346917.
↑ Walshaw, D.L., Lowthorpe, S., East, A. and Poole, P.S. (1997). „Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity”. FEBS Lett. 414: 397-401. PMID 9315727.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Polar-amino-acid-transporting+ATPase

[1] Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. (1995). „Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases”. Res. Microbiol. 146: 271-278. PMID 7569321.

[2] Saier, M.H., Jr. (1998). „Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya”. Adv. Microb. Physiol. 40: 81-136. PMID 9889977.

[3] Nikaido, K., Liu, P.Q. and Ferro-Luzzi Ames, G. (1997). „Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubilization, dimerization , and ATPase activity”. J. Biol. Chem. 272: 27745-27752. PMID 9346917.

[4] Walshaw, D.L., Lowthorpe, S., East, A. and Poole, P.S. (1997). „Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity”. FEBS Lett. 414: 397-401. PMID 9315727.

[1]

[2]

[3]

[4]