Transportujuća ATPaza ksenobiotika

Transportujuća ATPaza ksenobiotika
Identifikatori
EC broj 3.6.3.44
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Transportujuća ATPaza ksenobiotika (EC 3.6.3.44, protein otpornosti na višestruke lekove, MDR protein, P-glikoprotein, protein pleiotropske otpornosti na lekove, PDR protein, ATPaza steroidnog transporta, ATP fosfohidrolaza (eksport steroida)) je enzim sa sistematskim imenom ATP fosfohidrolaza (eksport ksenobiotika).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + H2O + ksenobiotikin ADP + fosfat + ksenobiotikout

Ova ATPaza ABC-tipa je karakteristična po prisustvu dva slična ATP-vezujuća domena.

Reference

  1. ↑ Bellamy, W.T. (1996). „P-glycoproteins and multidrug resistance”. Annu. Rev. Pharmacol. Toxicol. 36: 161-183. PMID 8725386. 
  2. ↑ Frijters, C.M., Ottenhoff, R., Van Wijland, M.J., Van Nieuwkerk, C., Groen, A.K. and Oude-Elferink, R.P. (1996). „Influence of bile salts on hepatic mdr2 P-glycoprotein expression”. Adv. Enzyme Regul. 36: 351-363. PMID 8869755. 
  3. ↑ Keppler, D., König, J. and Buchler, M. (1997). „The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes”. Adv. Enzyme Regul. 37: 321-333. PMID 9381978. 
  4. ↑ Loe, D.W., Deeley, R.G. and Cole, S.P. (1998). „Characterization of vincristine transport by the Mr 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione”. Cancer Res. 58: 5130-5136. PMID 9823323. 
  5. ↑ van Veen, H.W. and Konings, W.N. (1998). „The ABC family of multidrug transporters in microorganisms”. Biochim. Biophys. Acta 1365: 31-36. PMID 9693718. 
  6. ↑ Griffiths, J.K. and Sansom, C.E. (1998). The Transporter Factsbook. San Diego: Academic Press. str. -. 
  7. ↑ Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995). „Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals”. Curr. Genet. 27: 320-329. PMID 7614555. 
  8. ↑ Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K. and Yamasaki, M. (1995). „bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily”. J. Bacteriol. 177: 1536-1543. PMID 7883711. 
  9. ↑ Mahé, Y., Lemoine, Y. and Kuchler, K. (1996). „The ATP-binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo”. J. Biol. Chem. 271: 25167-25172. PMID 8810273. 

Literatura

  • Griffiths, J.K. and Sansom, C.E. (1998). The Transporter Factsbook. San Diego: Academic Press. str. -. 

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