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Timidilat sintaza
	Timidilat sintaza dimer, Human
Identifikatori
EC broj	2.1.1.45
CAS broj	9031-61-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Timidilat sintaza (EC 2.1.1.45, dTMP sintaza, timidilatna sintetaza, metilintetrahidrofolat:dUMP C-metiltransferaza, TMP sintetaza) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat:dUMP C-metiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

5,10-metilintetrahidrofolat + dUMP

\rightleftharpoons

dihidrofolat + dTMP

Reference

↑ Blakley, R.L. (1963). „The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase”. J. Biol. Chem. 238: 2113-2118.
↑ Lockshin, A., Moran, R.G. and Danenberg, P.V. (1979). „Thymidylate synthetase purified to homogeneity from human leukemic cells”. Proc. Natl. Acad. Sci. USA 76: 750-754. PMID 34155.
↑ Slavik, K. and Slavikova, V. (1980). „Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography”. Methods Enzymol. 66: 709-723. PMID 6990200.
↑ Wahba, A.J. and Friedkin, M. (1962). „The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli”. J. Biol. Chem. 237: 3794-3801. PMID 13998281.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Thymidylate+synthase

[1] Blakley, R.L. (1963). „The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase”. J. Biol. Chem. 238: 2113-2118.

[2] Lockshin, A., Moran, R.G. and Danenberg, P.V. (1979). „Thymidylate synthetase purified to homogeneity from human leukemic cells”. Proc. Natl. Acad. Sci. USA 76: 750-754. PMID 34155.

[3] Slavik, K. and Slavikova, V. (1980). „Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography”. Methods Enzymol. 66: 709-723. PMID 6990200.

[4] Wahba, A.J. and Friedkin, M. (1962). „The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli”. J. Biol. Chem. 237: 3794-3801. PMID 13998281.

[1]

[2]

[3]

[4]

Timidilatna sintaza

Reference

Literatura

Vanjske veze