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Thermospermin sintaza
Identifikatori
EC broj	2.5.1.79
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Thermospermin sintaza (EC 2.5.1.79, TSPMS, ACL5, SAC51) je enzim sa sistematskim imenom S-adenozilmetioninamin:spermidin 3-aminopropiltransferaza (termospermin sinteza).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozilmetioninamin + spermidin

\rightleftharpoons

S-metil-5'-tioadenozin + termospermin + H⁺

Ovaj enzim je neophodan za korektnu specifikaciju ksilema, što se ostvaruje putem regulacije životnog veka ksilemskih elemenata.

Reference

↑ Romer, P., Faltermeier, A., Mertins, V., Gedrange, T., Mai, R. and Proff, P. (2008). „Investigations about N-aminopropyl transferases probably involved in biomineralization”. J. Physiol. Pharmacol. 59 Suppl 5: 27-37. PMID 19075322.
↑ Knott, J.M., Romer, P. and Sumper, M. (2007). „Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine”. FEBS Lett. 581: 3081-3086. PMID 17560575.
↑ Muniz, L., Minguet, E.G., Singh, S.K., Pesquet, E., Vera-Sirera, F., Moreau-Courtois, C.L., Carbonell, J., Blazquez, M.A. and Tuominen, H. (2008). „ACAULIS5 controls Arabidopsis xylem specification through the prevention of premature cell death”. Development 135: 2573-2582. PMID 18599510.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Thermospermine+synthase

[1] Romer, P., Faltermeier, A., Mertins, V., Gedrange, T., Mai, R. and Proff, P. (2008). „Investigations about N-aminopropyl transferases probably involved in biomineralization”. J. Physiol. Pharmacol. 59 Suppl 5: 27-37. PMID 19075322.

[2] Knott, J.M., Romer, P. and Sumper, M. (2007). „Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine”. FEBS Lett. 581: 3081-3086. PMID 17560575.

[3] Muniz, L., Minguet, E.G., Singh, S.K., Pesquet, E., Vera-Sirera, F., Moreau-Courtois, C.L., Carbonell, J., Blazquez, M.A. and Tuominen, H. (2008). „ACAULIS5 controls Arabidopsis xylem specification through the prevention of premature cell death”. Development 135: 2573-2582. PMID 18599510.

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