PROFILPELAJAR.COM

Tetrahidrofolatna sintaza
Identifikatori
EC broj	6.3.2.17
CAS broj	63363-84-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Tetrahidrofolatna sintaza (EC 6.3.2.17, folilpoliglutamatna sintaza, folat poliglutamatna sintetaza, formiltetrahidropteroildiglutamatna sintetaza, N¹⁰-formiltetrahidropteroildiglutamat sintetaza, folilpoli-gama-glutamatna sintaza, folilpoliglutamil sintetaza, folilpoli(gama-glutamat) sintaza, folilpoliglutamatna sintetaza, folilpoli-gama-glutamat sintetaza-dihidrofolatna sintetaza, FPGS, tetrahidrofolilpoliglutamat sintaza, tetrahidrofolat:L-glutamat gama-ligaza (formira ADP), tetrahidropteroil-(gama-Glu)_n:L-glutamat gama-ligaza (formira ADP)) je enzim sa sistematskim imenom tetrahidropteroil-gama-poliglutamat:L-glutamat gama-ligaza (formira ADP).^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + tetrahidropteroil-[gama-Glu]_n + L-glutamat

\rightleftharpoons

ADP + fosfat + tetrahidropteroil-[gama-Glu]_n+1

Kod pojedinih bakterija, isti protein katalizuje ovu reakciju i reakciju enzima EC 6.3.2.12.

Reference

↑ Cichowicz, D., Foo, S.K. and Shane, B. (1981). „Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells”. Mol. Cell. Biochem. 39: 209-228. PMID 6458762.
↑ McGuire, J.J. and Bertino, J.R. (1981). „Enzymatic synthesis and function of folylpolyglutamates”. Mol. Cell. Biochem. 38: 19-48. PMID 7027025.
↑ Bognar, A.L., Osborne, C., Shane, B., Singer, S.C. and Ferone, R. (1985). „Folylpoly-γ-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product”. J. Biol. Chem. 260: 5625-5630. PMID 2985605.
↑ Ravanel, S., Cherest, H., Jabrin, S., Grunwald, D., Surdin-Kerjan, Y., Douce, R. and Rébeillé, F. (2001). „Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA 98: 15360-15365. PMID 11752472.
↑ Cossins, E.A. and Chen, L. (1997). „Folates and one-carbon metabolism in plants and fungi”. Phytochemistry 45: 437-452. PMID 9190084.
↑ Cherest, H., Thomas, D. and Surdin-Kerjan, Y. (2000). „Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae”. J. Biol. Chem. 275: 14056-14063. PMID 10799479.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Tetrahydrofolate+synthase

[1] Cichowicz, D., Foo, S.K. and Shane, B. (1981). „Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells”. Mol. Cell. Biochem. 39: 209-228. PMID 6458762.

[2] McGuire, J.J. and Bertino, J.R. (1981). „Enzymatic synthesis and function of folylpolyglutamates”. Mol. Cell. Biochem. 38: 19-48. PMID 7027025.

[3] Bognar, A.L., Osborne, C., Shane, B., Singer, S.C. and Ferone, R. (1985). „Folylpoly-γ-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product”. J. Biol. Chem. 260: 5625-5630. PMID 2985605.

[4] Ravanel, S., Cherest, H., Jabrin, S., Grunwald, D., Surdin-Kerjan, Y., Douce, R. and Rébeillé, F. (2001). „Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA 98: 15360-15365. PMID 11752472.

[5] Cossins, E.A. and Chen, L. (1997). „Folates and one-carbon metabolism in plants and fungi”. Phytochemistry 45: 437-452. PMID 9190084.

[6] Cherest, H., Thomas, D. and Surdin-Kerjan, Y. (2000). „Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae”. J. Biol. Chem. 275: 14056-14063. PMID 10799479.

[1]

[2]

[3]

[4]

[5]

[6]