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Teobromin sintaza
Identifikatori
EC broj	2.1.1.159
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Teobromin sintaza (EC 2.1.1.159, monometilksantinska metiltransferaza, MXMT, CTS1, CTS2, S-adenozil-L-metionin:7-metilksantin 3-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:7-metilksantin N³-metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + 7-metilksantin

\rightleftharpoons

S-adenozil-L-homocistein + 3,7-dimetilksantin

Ovo je treći enzim u biosintezi kofeina. Enzim takođe može da katalizuje konverziju paraksantina u kofein.

Reference

↑ Ogawa, M., Herai, Y., Koizumi, N., Kusano, T. and Sano, H. (2001). „7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties”. J. Biol. Chem. 276: 8213-8218. PMID 11108716.
↑ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372-380. PMID 12746542.
↑ Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). „Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme”. Mol. Genet. Genomics 275: 125-135. PMID 16333668.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Theobromine+synthase

[1] Ogawa, M., Herai, Y., Koizumi, N., Kusano, T. and Sano, H. (2001). „7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties”. J. Biol. Chem. 276: 8213-8218. PMID 11108716.

[2] Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372-380. PMID 12746542.

[3] Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). „Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme”. Mol. Genet. Genomics 275: 125-135. PMID 16333668.

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