TRNK pseudouridinska38/39 sintaza

TRNK pseudouridinska^38/39 sintaza (EC 5.4.99.45, Deg1, Pus3p, pseudouridin sintaza 3) je enzim sa sistematskim imenom tRNK-uridin^38/39 uracil mutaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

tRNK uridin^38/39

\rightleftharpoons

tRNK pseudouridin^38/39

Enzim iz Saccharomyces cerevisiae je aktivan samo na uridinu³⁸ i uridinu³⁹.

Reference

↑ Lecointe, F., Simos, G., Sauer, A., Hurt, E.C., Motorin, Y. and Grosjean, H. (1998). „Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of Ψ³⁸ and Ψ³⁹ in tRNA anticodon loop”. J. Biol. Chem. 273: 1316-1323. PMID 9430663.
↑ Chen, J. and Patton, J.R. (2000). „Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA”. Biochemistry 39: 12723-12730. PMID 11027153.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH TRNA+pseudouridine38/39+synthase

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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