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TRNK intron endonukleaza
Identifikatori
EC broj	3.1.27.9
CAS broj	117444-13-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

TRNK intron endonukleaza (EC 3.1.27.9, transferna ribonukleat intronska endoribonukleaza, tRNK splajsujuća endonukleaza, splajsujuća endonukleaza, tRNKTRPintron endonukleaza, transferna splajsujuća endonukleaza) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endonukleolitičko razlaganje pre-tRNK, formiranje 5'-hidroksi i 2',3'-ciklično fosfatnih krajeva, i specifično uklanjanje introna

Ovaj enzim katalizuje finalni stupanj maturacije tRNK molekula.

Reference

↑ Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. (1985). „Structural alterations in mutant precursors of the yeast tRNA^Leu³ gene which behave as defective substrates for a highly purified splicing endoribonuclease”. EMBO J. 4: 3289-3297. PMID 3937725.
↑ Peebles, C.L., Gegenheimer, P. and Abelson, J. (1983). „Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease”. Cell 32: 525-536. PMID 6186398.
↑ Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. (1989). „Transfer RNA intron processing in the halophilic archaebacteria”. Can. J. Microbiol. 35: 36-42. PMID 2470486.
↑ Thompson, L.D. and Daniels, C.J. (1988). „A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties”. J. Biol. Chem. 263: 17951-17959. PMID 3192521.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH TRNA-intron+endonuclease

[1] Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. (1985). „Structural alterations in mutant precursors of the yeast tRNA^Leu³ gene which behave as defective substrates for a highly purified splicing endoribonuclease”. EMBO J. 4: 3289-3297. PMID 3937725.

[2] Peebles, C.L., Gegenheimer, P. and Abelson, J. (1983). „Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease”. Cell 32: 525-536. PMID 6186398.

[3] Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. (1989). „Transfer RNA intron processing in the halophilic archaebacteria”. Can. J. Microbiol. 35: 36-42. PMID 2470486.

[4] Thompson, L.D. and Daniels, C.J. (1988). „A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties”. J. Biol. Chem. 263: 17951-17959. PMID 3192521.

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