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Sulfit reduktaza (NADPH)
Identifikatori
EC broj	1.8.1.2
CAS broj	9029-35-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Sulfit reduktaza (NADPH) (EC 1.8.1.2, sulfit (redukovani nikotinamid adenin dinukleotid fosfat) reduktaza, NADPH-sulfitna reduktaza, NADPH-zavisna sulfitna reduktaza, H₂S-NADP oksidoreduktaza, sulfitna reduktaza (NADPH₂)) je enzim sa sistematskim imenom vodonik-sulfid:NADP⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

vodonik sulfid + 3 NADP⁺ + 3H₂O

\rightleftharpoons

sulfit + 3 NADPH + 3 H⁺

Ovaj enzim je gvozdeni flavoprotein (FAD i FMN).

Reference

↑ Hilz, H., Kittler, M. and Knape, G. (1959). „Die Reduktion von Sulfate in der Hefe”. Biochem. Z. 332: 151-166. PMID 14401842.
↑ Siegel, L.M., Murphy, M.J. and Kamin, H. (1973). „Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups”. J. Biol. Chem. 248: 251-264. PMID 4144254.
↑ Yoshimoto, A. and Sato, R. (1968). „Studies on yeast sulfite reductase. I. Purification and characterization”. Biochim. Biophys. Acta 153: 555-575. PMID 4384979.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Sulfite+reductase+(NADPH)

[1] Hilz, H., Kittler, M. and Knape, G. (1959). „Die Reduktion von Sulfate in der Hefe”. Biochem. Z. 332: 151-166. PMID 14401842.

[2] Siegel, L.M., Murphy, M.J. and Kamin, H. (1973). „Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups”. J. Biol. Chem. 248: 251-264. PMID 4144254.

[3] Yoshimoto, A. and Sato, R. (1968). „Studies on yeast sulfite reductase. I. Purification and characterization”. Biochim. Biophys. Acta 153: 555-575. PMID 4384979.

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