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Sulfid-citohrom-c reduktaza (flavocitohrom c)
Identifikatori
EC broj	1.8.2.3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Sulfid-citohrom-c reduktaza (flavocitohrom c) (EC 1.8.2.3, sulfid citohrom c reduktaza (flavocitohrom c)) je enzim sa sistematskim imenom hidrogen-sulfid:flavocitohrom c oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju:

vodonik sulfid + 2 fericitohrom c

\rightleftharpoons

sumpor + 2 ferocitohrom c + 2 H⁺

Ovaj enzim iz Allochromatium vinosum sadrži kovalentno vezani FAD i kovalentno-vezane c-tip hemove.

Reference

↑ Kusai, K. and Yamanaka, T. (1973). „The oxidation mechanisms of thiosulphate and sulphide in Chlorobium thiosulphatophilum: roles of cytochrome c-551 and cytochrome c-553”. Biochim. Biophys. Acta 325: 304-314. PMID 4357558.
↑ Fukumori, Y. and Yamanaka, T. (1979). „Flavocytochrome c of Chromatium vinosum. Some enzymatic properties and subunit structure”. J. Biochem. 85: 1405-1414. PMID 222744.
↑ Gray, G.O., Gaul, D.F. and Knaff, D.B. (1983). „Partial purification and characterization of two soluble c-type cytochromes from Chromatium vinosum”. Arch. Biochem. Biophys. 222: 78-86. PMID 6301383.
↑ Chen, Z.W., Koh, M., Van Driessche, G., Van Beeumen, J.J., Bartsch, R.G., Meyer, T.E., Cusanovich, M.A. and Mathews, F.S. (1994). „The structure of flavocytochrome c sulfide dehydrogenase from a purple phototrophic bacterium”. Science 266: 430-432. PMID 7939681.
↑ Sorokin, D.Yu, de Jong, G.A., Robertson, L.A. and Kuenen, G.J. (1998). „Purification and characterization of sulfide dehydrogenase from alkaliphilic chemolithoautotrophic sulfur-oxidizing bacteria”. FEBS Lett. 427: 11-14. PMID 9613590.
↑ Kostanjevecki, V., Brige, A., Meyer, T.E., Cusanovich, M.A., Guisez, Y. and van Beeumen, J. (2000). „A membrane-bound flavocytochrome c-sulfide dehydrogenase from the purple phototrophic sulfur bacterium Ectothiorhodospira vacuolata”. J. Bacteriol. 182: 3097-3103. PMID 10809687.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Sulfide-cytochrome-c+reductase+(flavocytochrome+c)

[1] Kusai, K. and Yamanaka, T. (1973). „The oxidation mechanisms of thiosulphate and sulphide in Chlorobium thiosulphatophilum: roles of cytochrome c-551 and cytochrome c-553”. Biochim. Biophys. Acta 325: 304-314. PMID 4357558.

[2] Fukumori, Y. and Yamanaka, T. (1979). „Flavocytochrome c of Chromatium vinosum. Some enzymatic properties and subunit structure”. J. Biochem. 85: 1405-1414. PMID 222744.

[3] Gray, G.O., Gaul, D.F. and Knaff, D.B. (1983). „Partial purification and characterization of two soluble c-type cytochromes from Chromatium vinosum”. Arch. Biochem. Biophys. 222: 78-86. PMID 6301383.

[4] Chen, Z.W., Koh, M., Van Driessche, G., Van Beeumen, J.J., Bartsch, R.G., Meyer, T.E., Cusanovich, M.A. and Mathews, F.S. (1994). „The structure of flavocytochrome c sulfide dehydrogenase from a purple phototrophic bacterium”. Science 266: 430-432. PMID 7939681.

[5] Sorokin, D.Yu, de Jong, G.A., Robertson, L.A. and Kuenen, G.J. (1998). „Purification and characterization of sulfide dehydrogenase from alkaliphilic chemolithoautotrophic sulfur-oxidizing bacteria”. FEBS Lett. 427: 11-14. PMID 9613590.

[6] Kostanjevecki, V., Brige, A., Meyer, T.E., Cusanovich, M.A., Guisez, Y. and van Beeumen, J. (2000). „A membrane-bound flavocytochrome c-sulfide dehydrogenase from the purple phototrophic sulfur bacterium Ectothiorhodospira vacuolata”. J. Bacteriol. 182: 3097-3103. PMID 10809687.

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