Skvalen—hopenska ciklaza
Skvalen—hopenska ciklaza (EC 5.4.99.17, Squalene—hopene cyclase) je enzim sa sistematskim imenom skvalen mutaza (ciklizacija, formira hop-22(29)-en).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- skvalen hop-22(29)-en
Ovaj enzim takođe formira ciklizacioni produk hopan-22-ol.
Reference
- ↑ Hoshino, T. and Sato, T. (2002). „Squalene-hopene cyclase: catalytic mechanism and substrate recognition”. Chem. Commun.: 291-301. PMID 12120044.
- ↑ Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. (2004). „Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring”. Org Biomol Chem 2: 1456-1470. PMID 15136801.
- ↑ Sato, T., Kouda, M. and Hoshino, T. (2004). „Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius”. Biosci. Biotechnol. Biochem. 68: 728-738. PMID 15056909.
- ↑ Reinert, D.J., Balliano, G. and Schulz, G.E. (2004). „Conversion of squalene to the pentacarbocyclic hopene”. Chem. Biol. 11: 121-126. PMID 15113001.
Literatura
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