Skvalen—hopanolna ciklaza

Skvalen—hopanolna ciklaza
Identifikatori
EC broj 4.2.1.129
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Skvalen—hopanolna ciklaza (EC 4.2.1.129, skvalen—hopenska ciklaza) je enzim sa sistematskim imenom hopan-22-ol hidrolijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

hopan-22-ol skvalen + H2O

Ovaj enzim formira ciklizacione produkte hopena (cf. EC 5.4.99.17) i hopanola iz skvalena u konstantnom odnosu 5:1.

Reference

  1. ↑ Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. (2004). „Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring”. Org Biomol Chem 2: 1456-1470. PMID 15136801. 
  2. ↑ Sato, T., Kouda, M. and Hoshino, T. (2004). „Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius”. Biosci. Biotechnol. Biochem. 68: 728-738. PMID 15056909. 

Literatura

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