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Sfinganin C4-monooksigenaza
Identifikatori
EC broj	1.14.13.169
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Sfinganin C4-monooksigenaza (EC 1.14.13.169, sfingolipidna C4-hidroksilaza, SUR2 (gen), SBH1 (gen), SBH2 (gen)) je enzim sa sistematskim imenom sfinganin,NADPH:kiseonik oksidoreduktaza (C4-hidroksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

sfinganin + NADPH + H⁺ + O₂

\rightleftharpoons

fitosfingozin + NADP⁺ + H₂O

Ovaj enzim učestvuje u biosintezi sfingolipida kod kvasca i biljki.

Reference

↑ Haak, D., Gable, K., Beeler, T. and Dunn, T. (1997). „Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p”. J. Biol. Chem. 272: 29704-29710. PMID 9368039.
↑ Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. (1998). „Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae”. J. Biol. Chem. 273: 11062-11068. PMID 9556590.
↑ Sperling, P., Ternes, P., Moll, H., Franke, S., Zahringer, U. and Heinz, E. (2001). „Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana”. FEBS Lett 494: 90-94. PMID 11297741.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Sphinganine+C4-monooxygenase

[1] Haak, D., Gable, K., Beeler, T. and Dunn, T. (1997). „Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p”. J. Biol. Chem. 272: 29704-29710. PMID 9368039.

[2] Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. (1998). „Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae”. J. Biol. Chem. 273: 11062-11068. PMID 9556590.

[3] Sperling, P., Ternes, P., Moll, H., Franke, S., Zahringer, U. and Heinz, E. (2001). „Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana”. FEBS Lett 494: 90-94. PMID 11297741.

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