Saharoza—1,6-a-glukan 3(6)-a-glukoziltransferaza

Saharoza—1,6-a-glukan 3(6)-a-glukoziltransferaza
Identifikatori
EC broj 2.4.1.125
CAS broj 81725-87-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Saharoza—1,6-a-glukan 3(6)-a-glukoziltransferaza (EC 2.4.1.125, u vodi rastvorna glukanska sintaza, GTF-I, GTF-S, GTF-SI, saharoza-1,6-alfa-glukan 3(6)-alfa-glukoziltransferaza, saharoza:1,6-alfa-D-glukan 3-alfa- and 6-alfa-glukoziltransferaza, saharoza:1,6-, 1,3-alfa-D-glukan 3-alfa- and 6-alfa-D-glukoziltransferaza, saharoza:1,6-alfa-D-glukan 3(6)-alfa-D-glukoziltransferaza, gtfB (gen), gtfC (gen), gtfD (gen)) je enzim sa sistematskim imenom saharoza:(1->6)-alfa-D-glukan 3(6)-alfa-D-glukoziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) saharoza + [(1->6)-alfa-D-glukozil]n D-fruktoza + [(1->6)-alfa-D-glukozil]n+1
(2) saharoza + [(1->6)-alfa-D-glukozil]n D-fruktoza + (1->3)-alfa-D-glukozil[(1->6)-alfa-D-glukozil]n

Ovaj enzim je izolovan iz bakterije dentalnog karijesa Streptococcus mutans.

Reference

  1. ↑ Mukasa, H., Shimamura, A. and Tsumori, H. (1982). „Purification and characterization of basic glucosyltransferase from Streptococcus mutans serotype c”. Biochim. Biophys. Acta 719: 81-89. PMID 6216919. 
  2. ↑ Shimamura, A., Tsumori, H. and Mukasa, H. (1982). „Purification and properties of Streptococcus mutans extracellular glucosyltransferase”. Biochim. Biophys. Acta 702: 72-80. PMID 6461359. 
  3. ↑ Tsumori, H., Shimamura, A. and Mukasa, H. (1985). „Purification and properties of extracellular glucosyltransferase synthesizing 1,6-, 1,3-α-D-glucan from Streptococcus mutans serotype a”. J. Gen. Microbiol. 131: 3347-3353. PMID 2937877. 
  4. ↑ Fujiwara, T., Tamesada, M., Bian, Z., Kawabata, S., Kimura, S. and Hamada, S. (1996). „Deletion and reintroduction of glucosyltransferase genes of Streptococcus mutans and role of their gene products in sucrose dependent cellular adherence”. Microb Pathog 20: 225-233. PMID 8737492. 
  5. ↑ Monchois, V., Willemot, R.M. and Monsan, P. (1999). „Glucansucrases: mechanism of action and structure-function relationships”. FEMS Microbiol. Rev. 23: 131-151. PMID 10234842. 
  6. ↑ Ito, K., Ito, S., Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A.D. and Iwata, S. (2011). „Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans”. J. Mol. Biol. 408: 177-186. PMID 21354427. 

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