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Ribonukleaza T2
Identifikatori
EC broj	3.1.27.1
CAS broj	37278-25-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Ribonukleaza T2 (EC 3.1.27.1, ribonukleaza II, bazno nespecifična ribonukleaza, RNaza (bazno nespecifična), ribonukleaza bez bazne specifičnosti, nespecifična RNaza, RNaza Ms, RNaza M, RNaza II, Escherichia coli ribonukleaza II, ribonukleat nukleotido-2'-transferaza (ciklizacija), kiselinska ribonukleaza, RNKaza CL, Escherichia coli ribonukleaza I' ribonukleaza PP2, ribonukleaza N2, ribonukleaza M, kiselinska RNaza, ribonukleaza (bazno nespecifična), ribonukleaza (bazno nespecifična), RNaza T2, ribonukleaza PP3, ribonukleat 3'-oligonukleotidna hidrolaza, RNaza II, ribonukleaza U4) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Dvostepeno endonukleolitičko razlaganje do nukleozid 3'-fosfata i 3'-fosfooligonukleotida sa 2',3'-cikličnim fosfatnim intermedijerima

Reference

↑ Garcia-Segura, J.M., Orozco, M.M., Fominaya, J.M. and Gavilanes, J.G. (1986). „Purification, molecular and enzymic characterization of an acid RNase from the insect Ceratitis capitata”. Eur. J. Biochem. 158: 367-372. PMID 3732273.
↑ Heppel, L.A. (1966). „Pig liver nuclei ribonuclease”. u: Cantoni, G.L. and Davies, D.R.. Procedures in Nucleic Acid Research. New York: Procedures in Nucleic Acid Research. str. 31-36.
↑ Reddi, K.K. and Mauser, L.J. (1965). „Studies on the formation of tobacco mosaic virus ribonucleic acid. VI. Mode of degradation of host ribonucleic acid to ribonucleosides and their conversion to ribonucleoside 5′-phosphates”. Proc. Natl. Acad. Sci. USA 53: 607-613. PMID 14338240.
↑ Uchida, I. and Egami, F. (1967). „The specificity of ribonuclease T₂”. J. Biochem. (Tokyo) 61: 44-53. PMID 6048969.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Heppel, L.A. (1966). „Pig liver nuclei ribonuclease”. u: Cantoni, G.L. and Davies, D.R.. Procedures in Nucleic Acid Research. New York: Procedures in Nucleic Acid Research. str. 31-36.

Vanjske veze

MeSH Ribonuclease+T2

[1] Garcia-Segura, J.M., Orozco, M.M., Fominaya, J.M. and Gavilanes, J.G. (1986). „Purification, molecular and enzymic characterization of an acid RNase from the insect Ceratitis capitata”. Eur. J. Biochem. 158: 367-372. PMID 3732273.

[2] Heppel, L.A. (1966). „Pig liver nuclei ribonuclease”. u: Cantoni, G.L. and Davies, D.R.. Procedures in Nucleic Acid Research. New York: Procedures in Nucleic Acid Research. str. 31-36.

[3] Reddi, K.K. and Mauser, L.J. (1965). „Studies on the formation of tobacco mosaic virus ribonucleic acid. VI. Mode of degradation of host ribonucleic acid to ribonucleosides and their conversion to ribonucleoside 5′-phosphates”. Proc. Natl. Acad. Sci. USA 53: 607-613. PMID 14338240.

[4] Uchida, I. and Egami, F. (1967). „The specificity of ribonuclease T₂”. J. Biochem. (Tokyo) 61: 44-53. PMID 6048969.

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