RAP1A

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RAP1A, član RAS familije onkogena

PDB prikaz baziran na 1c1y.
Dostupne strukture
1C1Y, 1GUA, 3KUC
Identifikatori
SimboliRAP1A; KREV-1; KREV1; RAP1; SMGP21
Vanjski IDOMIM: 179520 MGI: 97852 HomoloGene: 2162 GeneCards: RAP1A Gene
Ortolozi
VrstaČovekMiš
Entrez5906109905
EnsemblENSG00000116473ENSMUSG00000068798
UniProtP62834P62835
RefSeq (mRNA)NM_001010935.1NM_145541.4
RefSeq (protein)NP_001010935.1NP_663516.1
Lokacija (UCSC)Chr 1:
112.08 - 112.26 Mb		Chr 3:
105.53 - 105.6 Mb
PubMed pretraga[1][2]

Ras srodni protein 1A je protein koji je kod ljudi kodiran RAP1A genom.[1]

Interakcije

RAP1A formira interakcije sa C-Raf,[2][3][4][5] PDE6D,[6][7] TSC2,[8][9] RALGDS,[10][11] RAPGEF2[12] i MLLT4.[10]

Reference

  1. ↑ Kawata M, Matsui Y, Kondo J, Hishida T, Teranishi Y, Takai Y (January 1989). „A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization”. J Biol Chem 263 (35): 18965–71. PMID 3143720. 
  2. ↑ Han, L; Colicelli J (March 1995). „A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1”. Mol. Cell. Biol. (UNITED STATES) 15 (3): 1318–23. ISSN 0270-7306. PMC 230355. PMID 7862125. 
  3. ↑ Nassar, N; Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A (June 1995). „The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue”. Nature (ENGLAND) 375 (6532): 554–60. DOI:10.1038/375554a0. ISSN 0028-0836. PMID 7791872. 
  4. ↑ Hu, C D; Kariya K, Okada T, Qi X, Song C, Kataoka T (January 1999). „Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation”. J. Biol. Chem. (UNITED STATES) 274 (1): 48–51. DOI:10.1074/jbc.274.1.48. ISSN 0021-9258. PMID 9867809. 
  5. ↑ Okada, T; Hu C D, Jin T G, Kariya K, Yamawaki-Kataoka Y, Kataoka T (September 1999). „The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases”. Mol. Cell. Biol. (UNITED STATES) 19 (9): 6057–64. ISSN 0270-7306. PMC 84512. PMID 10454553. 
  6. ↑ Nancy, Vanessa; Callebaut Isabelle, El Marjou Ahmed, de Gunzburg Jean (April 2002). „The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases”. J. Biol. Chem. (United States) 277 (17): 15076–84. DOI:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539. 
  7. ↑ Hanzal-Bayer, Michael; Renault Louis, Roversi Pietro, Wittinghofer Alfred, Hillig Roman C (May 2002). „The complex of Arl2-GTP and PDE delta: from structure to function”. EMBO J. (England) 21 (9): 2095–106. DOI:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. 
  8. ↑ Castro, Ariel F; Rebhun John F, Clark Geoffrey J, Quilliam Lawrence A (August 2003). „Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner”. J. Biol. Chem. (United States) 278 (35): 32493–6. DOI:10.1074/jbc.C300226200. ISSN 0021-9258. PMID 12842888. 
  9. ↑ Yamamoto, Yuji; Jones Kathryn A, Mak Baldwin C, Muehlenbachs Atis, Yeung Raymond S (August 2002). „Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin”. Arch. Biochem. Biophys. (United States) 404 (2): 210–7. DOI:10.1016/S0003-9861(02)00300-4. ISSN 0003-9861. PMID 12147258. 
  10. ↑ 10,0 10,1 Boettner, B; Govek E E, Cross J, Van Aelst L (August 2000). „The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9064–9. DOI:10.1073/pnas.97.16.9064. ISSN 0027-8424. PMC 16822. PMID 10922060. 
  11. ↑ Nancy, V; Wolthuis R M, de Tand M F, Janoueix-Lerosey I, Bos J L, de Gunzburg J (March 1999). „Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2”. J. Biol. Chem. (UNITED STATES) 274 (13): 8737–45. DOI:10.1074/jbc.274.13.8737. ISSN 0021-9258. PMID 10085114. 
  12. ↑ Rebhun, J F; Castro A F, Quilliam L A (November 2000). „Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction”. J. Biol. Chem. (UNITED STATES) 275 (45): 34901–8. DOI:10.1074/jbc.M005327200. ISSN 0021-9258. PMID 10934204.