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Pteridin reduktaza
Identifikatori
EC broj	1.5.1.33
CAS broj	131384-61-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Pteridin reduktaza (EC 1.5.1.33, PTR1, pteridinska reduktaza 1) je enzim sa sistematskim imenom 5,6,7,8-tetrahidrobiopterin:NADP⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

5,6,7,8-tetrahidrobiopterin + 2 NADP⁺

\rightleftharpoons

biopterin + 2 NADPH + 2 H⁺

Ovaj enzim iz Leishmania katalizuje redukciju posredstvom NADPH. On deluje na folat i znatan broj drugih nekonjugovanih pterina, uključujući biopterin, do njihovih tetrahidro formi. On takođe katalizuje redukciju 7,8-dihidropterina i 7,8-dihidrofolata do njihovih tetrahidro formi.

Reference

↑ Nare, B., Hardy, L. and Beverley, S.M. (1997). „The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major”. J. Biol. Chem. 272: 13883-13891. PMID 9153248.
↑ Gourley, D.G., Schüttelkopf, A.W., Leonard, G.A., Luba, J., Hardy, L.W., Beverley, S.M. and Hunter, W.N. (2001). „Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites”. Nat. Struct. Biol. 8: 521-525. PMID 11373620.
↑ Fitzpatrick, P.F. (2000). „The aromatic amino acid hydroxylases”. Adv. Enzymol. Relat. Areas Mol. Biol. 74: 235-294. PMID 10800597.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Pteridine+reductase

[1] Nare, B., Hardy, L. and Beverley, S.M. (1997). „The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major”. J. Biol. Chem. 272: 13883-13891. PMID 9153248.

[2] Gourley, D.G., Schüttelkopf, A.W., Leonard, G.A., Luba, J., Hardy, L.W., Beverley, S.M. and Hunter, W.N. (2001). „Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites”. Nat. Struct. Biol. 8: 521-525. PMID 11373620.

[3] Fitzpatrick, P.F. (2000). „The aromatic amino acid hydroxylases”. Adv. Enzymol. Relat. Areas Mol. Biol. 74: 235-294. PMID 10800597.

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