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Pseudotropin aciltransferaza
Identifikatori
EC broj	2.3.1.186
CAS broj	162535-26-4&title= 138440-78-5, 162535-26-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Pseudotropin aciltransferaza (EC 2.3.1.186, pseudotropin:acil-KoA transferaza, tigloil-KoA:pseudotropin aciltransferaza, acetil-KoA:pseudotropin aciltransferaza, pseudotropin acetiltransferaza, pseudotropin tigloiltransferaza, PAT) je enzim sa sistematskim imenom acil-KoA:pseudotropin O-aciltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-KoA + pseudotropin

\rightleftharpoons

KoA + O-acilpseudotropin

Ovaj enzim je apsolutno specifičan za endo/3alfa konfiguraciju tropina.

Reference

↑ Rabot, S., Peerless, A.C.J. and Robins, R.J. (1995). „Tigloyl-CoA:pseudotropine acyltransferase — an enzyme of tropane alkaloid biosynthesis”. Phytochemistry 39: 315-322.
↑ Robins, R.J., Bachmann, P., Robinson, T., Rhodes, M.J. and Yamada, Y. (1991). „The formation of 3α- and 3β-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases”. FEBS Lett. 292: 293-297. PMID 1959620.
↑ Robins, R.J., Bachmann,P., Peerless, A.C.J. and Rabot, S. (1994). „Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures”. Plant Cell, Tissue Organ Cult. 38: 241-247.
↑ Boswell, H.D., Dräger, B., McLauchlan, W.R., Portsteffen, A., Robins, D.J., Robins, R.J. and Walton, N.J. (1999). „Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura”. Phytochemistry 52: 871-878. PMID 10626376.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Pseudotropine+acyltransferase

[1] Rabot, S., Peerless, A.C.J. and Robins, R.J. (1995). „Tigloyl-CoA:pseudotropine acyltransferase — an enzyme of tropane alkaloid biosynthesis”. Phytochemistry 39: 315-322.

[2] Robins, R.J., Bachmann, P., Robinson, T., Rhodes, M.J. and Yamada, Y. (1991). „The formation of 3α- and 3β-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases”. FEBS Lett. 292: 293-297. PMID 1959620.

[3] Robins, R.J., Bachmann,P., Peerless, A.C.J. and Rabot, S. (1994). „Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures”. Plant Cell, Tissue Organ Cult. 38: 241-247.

[4] Boswell, H.D., Dräger, B., McLauchlan, W.R., Portsteffen, A., Robins, D.J., Robins, R.J. and Walton, N.J. (1999). „Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura”. Phytochemistry 52: 871-878. PMID 10626376.

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