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Prozolanapiron-II oksidaza
Identifikatori
EC broj	1.1.3.42
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Prozolanapiron-II oksidaza (EC 1.1.3.42, Sol5, SPS, solanapironska sintaza, prozolanapironska II oksidaza) je enzim sa sistematskim imenom prozolanapiron-II:kiseonik 3'-oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

prosolanapiron II + O₂

\rightleftharpoons

prosolanapiron III +H₂O₂

Ovaj enzim učestvuje u biosintezi fitotoksina solanapirona u nekim gljivama. On je bifunkcionalani enzim koji katalizuje oksidaciju prozolanapirona II i naknadnu Diels Alderovu cikloizomerizaciju produkta prozolanapirona III do (-)-solanapirona A (cf. EC 5.5.1.20, prozolanapiron III cikloizomeraza).

Reference

↑ Kasahara, K., Miyamoto, T., Fujimoto, T., Oguri, H., Tokiwano, T., Oikawa, H., Ebizuka, Y. and Fujii, I. (2010). „Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani”. Chembiochem. 11: 1245-1252. PMID 20486243.
↑ Katayama, K., Kobayashi, T., Oikawa, H., Honma, M. and Ichihara, A. (1998). „Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction”. Biochim. Biophys. Acta 1384: 387-395. PMID 9659400.
↑ Katayama, K., Kobayashi, T., Chijimatsu, M., Ichihara, A. and Oikawa, H. (2008). „Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani”. Biosci. Biotechnol. Biochem. 72: 604-607. PMID 18256508.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Prosolanapyrone-II+oxidase

[1] Kasahara, K., Miyamoto, T., Fujimoto, T., Oguri, H., Tokiwano, T., Oikawa, H., Ebizuka, Y. and Fujii, I. (2010). „Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani”. Chembiochem. 11: 1245-1252. PMID 20486243.

[2] Katayama, K., Kobayashi, T., Oikawa, H., Honma, M. and Ichihara, A. (1998). „Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction”. Biochim. Biophys. Acta 1384: 387-395. PMID 9659400.

[3] Katayama, K., Kobayashi, T., Chijimatsu, M., Ichihara, A. and Oikawa, H. (2008). „Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani”. Biosci. Biotechnol. Biochem. 72: 604-607. PMID 18256508.

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