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Protein-glutamat O-metiltransferaza
Identifikatori
EC broj	2.1.1.80
CAS broj	2613562
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Protein-glutamat O-metiltransferaza (EC 2.1.1.80, metil-prihvatajuća hemotaksna proteinska O-metiltransferaza, S-adenozilmetionin-glutamil metiltransferaza, metil-prihvatajuća hemotaksna proteinska metiltransferaza II, S-adenozilmetionin:protein-karboksil O-metiltransferaza, proteinska metilaza II, MCP metiltransferaza I, MCP metiltransferaza II, proteinska O-metiltransferaza, protein(aspartat)metiltransferaza, protein(karboksil)metiltransferaza, proteinska karboksil-metilaza, proteinska karboksil-O-metiltransferaza, proteinska karboksilmetiltransferaza II, proteinska karboksimetilaza, proteinska karboksimetiltransferaza, proteinska metiltransferaza II) je enzim sa sistematskim imenom S-adenozil-L-metionin:protein-L-glutamat O-metiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + protein L-glutamat

\rightleftharpoons

S-adenozil-L-homocistein + protein L-glutamat metil estar

Ovaj enzim formira estarske grupe sa L-glutamatnim ostacima brojnih membranskih proteina.

Reference

↑ Burgess-Cassler, A., Ulla, A.H.J. and Ordal, G.W. (1982). „Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II”. J. Biol. Chem. 257: 8412-8417. PMID 6806296.
↑ Kleene, S.J., Toews, M.L. and Adler, J. (1977). „Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis”. J. Biol. Chem. 252: 3214-3218. PMID 16888.
↑ Simms, S.A., Stock, A.M. and Stock, J.B. (1987). „Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria”. J. Biol. Chem. 262: 8537-8543. PMID 3298235.
↑ Springer, W.R. and Koshland, D.E., Jr. (1977). „Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system”. Proc. Natl. Acad. Sci. USA 74: 533-537. PMID 322131.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Protein-glutamate+O-methyltransferase

[1] Burgess-Cassler, A., Ulla, A.H.J. and Ordal, G.W. (1982). „Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II”. J. Biol. Chem. 257: 8412-8417. PMID 6806296.

[2] Kleene, S.J., Toews, M.L. and Adler, J. (1977). „Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis”. J. Biol. Chem. 252: 3214-3218. PMID 16888.

[3] Simms, S.A., Stock, A.M. and Stock, J.B. (1987). „Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria”. J. Biol. Chem. 262: 8537-8543. PMID 3298235.

[4] Springer, W.R. and Koshland, D.E., Jr. (1977). „Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system”. Proc. Natl. Acad. Sci. USA 74: 533-537. PMID 322131.

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