Protein-fruktozamin 3-kinaza

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Protein-fruktozamin 3-kinaza (EC 2.7.1.171, FN3K, fruktosaminska 3-kinaza) je enzim sa sistematskim imenom ATP:(protein)-N⁶-D-fruktosil-L-lizin 3-fosfotransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [protein]-N⁶-D-fruktozil-L-lizin

\rightleftharpoons

ADP + [protein]-N⁶-(3-O-fosfo-D-fruktozil)-L-lizin

Neenzimatska glikacija je važan faktor u patogenezi diabetičkih komplikacija.

Reference

↑ Szwergold, B.S., Howell, S. and Beisswenger, P.J. (2001). „Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo”. Diabetes 50: 2139-2147. PMID 11522682.
↑ Delpierre, G., Rider, M.H., Collard, F., Stroobant, V., Vanstapel, F., Santos, H. and Van Schaftingen, E. (2000). „Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase”. Diabetes 49: 1627-1634. PMID 11016445.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Protein-fructosamine+3-kinase

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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