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Prolilna oligopeptidaza
Identifikatori
EC broj	3.4.21.26
CAS broj	72162-84-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Prolilna oligopeptidaza (EC 3.4.21.26, enzim postprolinskog odvajanja, prolinsko specifična endopeptidaza, postprolinska endopeptidaza, prolinska endopeptidaza, endoprolilpeptidaza, prolilna endopeptidaza) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza -Pro- i u manjoj meri -Ala- u oligopeptidima

Ovaj enzim je prisutan u povrću i flavobakterijama.

Reference

↑ Walter, R. and Yoshimoto, T. (1978). „Postproline cleaving enzyme: kinetic studies of size and stereospecificity of its active site”. Biochemistry 17: 4139-4144. PMID 708698.
↑ Nomura, K. (1986). „Specificity of prolyl endopeptidase”. FEBS Lett. 209: 235-237. PMID 3539636.
↑ Moriyama, A., Nakanishi, M. and Sasaki, M. (1988). „Porcine muscle prolyl endopeptidase and its endogenous substrates”. J. Biochem. (Tokyo) 104: 112-117. PMID 2851585.
↑ Rennex, D., Hemmings, B.A., Hofsteenge, J. and Stone, S.R. (1991). „cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue”. Biochemistry, 30: 2195-2203. PMID 1900195.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Prolyl+oligopeptidase

[1] Walter, R. and Yoshimoto, T. (1978). „Postproline cleaving enzyme: kinetic studies of size and stereospecificity of its active site”. Biochemistry 17: 4139-4144. PMID 708698.

[2] Nomura, K. (1986). „Specificity of prolyl endopeptidase”. FEBS Lett. 209: 235-237. PMID 3539636.

[3] Moriyama, A., Nakanishi, M. and Sasaki, M. (1988). „Porcine muscle prolyl endopeptidase and its endogenous substrates”. J. Biochem. (Tokyo) 104: 112-117. PMID 2851585.

[4] Rennex, D., Hemmings, B.A., Hofsteenge, J. and Stone, S.R. (1991). „cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue”. Biochemistry, 30: 2195-2203. PMID 1900195.

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