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Proklavaminatna amidinohidrolaza
Identifikatori
EC broj	3.5.3.22
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Proklavaminatna amidinohidrolaza (EC 3.5.3.22, PAH, proklavaminatna amidino hidrolaza) je enzim sa sistematskim imenom amidinoproklavaminat amidinohidrolaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

amidinoproklavaminat + H₂O

\rightleftharpoons

proklavaminat + ureja

Ovaj enzim učestvuje u biositezi beta-laktamaznog inhibitora klavulanata u Streptomyces clavuligerus.

Reference

↑ Salowe, S.P., Krol, W.J., Iwatareuyl, D. and Townsend, C.A. (1991). „Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction”. Biochemistry 30: 2281-2292. PMID 1998687.
↑ Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A. and Solomon, E.I. (2001). „Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities”. J. Am. Chem. Soc. 123: 7388-7398. PMID 11472170.
↑ Townsend, C.A. (2002). „New reactions in clavulanic acid biosynthesis”. Curr. Opin. Chem. Biol. 6: 583-589. PMID 12413541.
↑ Wu, T.K., Busby, R.W., Houston, T.A., McIlwaine, D.B., Egan, L.A. and Townsend, C.A. (1995). „Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis”. J. Bacteriol. 177: 3714-3720. PMID 7601835.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Proclavaminate+amidinohydrolase

[1] Salowe, S.P., Krol, W.J., Iwatareuyl, D. and Townsend, C.A. (1991). „Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction”. Biochemistry 30: 2281-2292. PMID 1998687.

[2] Zhou, J., Kelly, W.L., Bachmann, B.O., Gunsior, M., Townsend, C.A. and Solomon, E.I. (2001). „Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities”. J. Am. Chem. Soc. 123: 7388-7398. PMID 11472170.

[3] Townsend, C.A. (2002). „New reactions in clavulanic acid biosynthesis”. Curr. Opin. Chem. Biol. 6: 583-589. PMID 12413541.

[4] Wu, T.K., Busby, R.W., Houston, T.A., McIlwaine, D.B., Egan, L.A. and Townsend, C.A. (1995). „Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis”. J. Bacteriol. 177: 3714-3720. PMID 7601835.

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