PROFILPELAJAR.COM

Piroglutamilna peptidaza II
Identifikatori
EC broj	3.4.19.6
CAS broj	60063-88-9
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Piroglutamilna peptidaza II (EC 3.4.19.6, tiroliberinaza, piroglutamilna aminopeptidaza II, , tirotropin-oslobađajući faktor piroglutamatna aminopeptidaza, piroglutamatna aminopeptidaza II, tiroliberin-hidrolizujuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća peptidaza, TRH aminopeptidaza) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje N-terminalne piroglutamilne grupe sa pGlu-His-Xaa tripeptida i pGlu-His-Xaa-Gly tetrapeptida

Ovaj enzim je visoko specifičan za tireotropin oslobađajući hormon.

Reference

↑ Bauer, K. and Nowak, P. (1979). „Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond”. Eur. J. Biochem. 99: 239-246. PMID 115687.
↑ O'Connor, B. and O'Cuinn, G. (1985). „Purification of and kinetic studies on a narrow specifity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain”. Eur. J. Biochem. 150: 47-52. PMID 2862039.
↑ Wilk, S. and Wilk, E.K. (1989). „Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme”. Neurochem. Int. 15: 81-89.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Pyroglutamyl-peptidase+II

[1] Bauer, K. and Nowak, P. (1979). „Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond”. Eur. J. Biochem. 99: 239-246. PMID 115687.

[2] O'Connor, B. and O'Cuinn, G. (1985). „Purification of and kinetic studies on a narrow specifity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain”. Eur. J. Biochem. 150: 47-52. PMID 2862039.

[3] Wilk, S. and Wilk, E.K. (1989). „Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme”. Neurochem. Int. 15: 81-89.

[1]

[2]

[3]