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Piridoksin 5'-fosfat sintaza
Identifikatori
EC broj	2.6.99.2
CAS broj	230310-47-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Piridoksin 5'-fosfat sintaza (EC 2.6.99.2, piridoksin 5-fosfat fosfo lijaza, PNP sintaza, PdxJ) je enzim sa sistematskim imenom 1-dezoksi-D-ksiluloza-5-fosfat:3-amino-2-oksopropil fosfat 3-amino-2-oksopropiltransferaza (fosfat-hidroliza; ciklizacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-dezoksi-D-ksiluloza 5-fosfat + 3-amino-2-oksopropil fosfat

\rightleftharpoons

piridoksin 5'-fosfat + fosfat + 2H₂O

Kod Escherichia coli, koenzim piridoksal 5'-fosfat se sintetizuje de novo.

Reference

↑ Garrido-Franco, M. (2003). „Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B₆ and beyond”. Biochim. Biophys. Acta 1647: 92-97. PMID 12686115.
↑ Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. (2002). „Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis”. J. Mol. Biol. 321: 601-612. PMID 12206776.
↑ Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45-48. PMID 10225425.
↑ Franco, M.G., Laber, B., Huber, R. and Clausen, T. (2001). „Structural basis for the function of pyridoxine 5′-phosphate synthase”. Structure 9: 245-253. PMID 11286891.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Pyridoxine+5'-phosphate+synthase

[1] Garrido-Franco, M. (2003). „Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B₆ and beyond”. Biochim. Biophys. Acta 1647: 92-97. PMID 12686115.

[2] Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. (2002). „Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis”. J. Mol. Biol. 321: 601-612. PMID 12206776.

[3] Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45-48. PMID 10225425.

[4] Franco, M.G., Laber, B., Huber, R. and Clausen, T. (2001). „Structural basis for the function of pyridoxine 5′-phosphate synthase”. Structure 9: 245-253. PMID 11286891.

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