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Pektatna trisaharid-lijaza
Identifikatori
EC broj	4.2.2.22
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Pektatna trisaharid-lijaza (EC 4.2.2.22, eksopektat-lijaza, pektat lijaza A, PelA) je enzim sa sistematskim imenom (1->4)-alfa-D-galakturonan redukujuči-kraj-trisaharid-lijaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Eliminativno odvajanje nezasićenog trigalakturonata kao glavnog produkta sa redukujućeg kraja poligalakturonske kiseline/pektata

Ovaj enzim prvenstveno uklanja trisaharid sa redukujućeg kraja.

Reference

↑ Kluskens, L.D., van Alebeek, G.J., Voragen, A.G., de Vos, W.M. and van der Oost, J. (2003). „Molecular and biochemical characterization of the thermoactive family 1 pectate lyase from the hyperthermophilic bacterium Thermotoga maritima”. Biochem. J. 370: 651-659. PMID 12443532.
↑ Tamaru, Y. and Doi, R.H. (2001). „Pectate lyase A, an enzymatic subunit of the Clostridium cellulovorans cellulosome”. Proc. Natl. Acad. Sci. USA 98: 4125-4129. PMID 11259664.
↑ Berensmeier, S., Singh, S.A., Meens, J. and Buchholz, K. (2004). „Cloning of the pelA gene from Bacillus licheniformis 14A and biochemical characterization of recombinant, thermostable, high-alkaline pectate lyase”. Appl. Microbiol. Biotechnol. 64: 560-567. PMID 14673544.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Pectate+trisaccharide-lyase

[1] Kluskens, L.D., van Alebeek, G.J., Voragen, A.G., de Vos, W.M. and van der Oost, J. (2003). „Molecular and biochemical characterization of the thermoactive family 1 pectate lyase from the hyperthermophilic bacterium Thermotoga maritima”. Biochem. J. 370: 651-659. PMID 12443532.

[2] Tamaru, Y. and Doi, R.H. (2001). „Pectate lyase A, an enzymatic subunit of the Clostridium cellulovorans cellulosome”. Proc. Natl. Acad. Sci. USA 98: 4125-4129. PMID 11259664.

[3] Berensmeier, S., Singh, S.A., Meens, J. and Buchholz, K. (2004). „Cloning of the pelA gene from Bacillus licheniformis 14A and biochemical characterization of recombinant, thermostable, high-alkaline pectate lyase”. Appl. Microbiol. Biotechnol. 64: 560-567. PMID 14673544.

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