Nitronat monooksigenaza

Nitronat monooksigenaza
Identifikatori
EC broj 1.13.12.16
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Nitronat monooksigenaza (EC 1.13.12.16, NMO) je enzim sa sistematskim imenom nitronat:kiseonik 2-oksidoreduktaza (formira nitrit).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

etilnitronat + O2 acetaldehid + nitrit + drugi produkti

Enzimi iz gljiva Neurospora crassa i kvasca Williopsis saturnus var. mrakii sadrže nekovalentno vezani FMN kao kofaktor.

Reference

  1. ↑ Francis, K., Russell, B. and Gadda, G. (2005). „Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase”. J. Biol. Chem. 280: 5195-5204. PMID 15582992. 
  2. ↑ Ha, J.Y., Min, J.Y., Lee, S.K., Kim, H.S., Kim do, J., Kim, K.H., Lee, H.H., Kim, H.K., Yoon, H.J. and Suh, S.W. (2006). „Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of the catalytic base”. J. Biol. Chem. 281: 18660-18667. PMID 16682407. 
  3. ↑ Gadda, G. and Francis, K. (2010). „Nitronate monooxygenase, a model for anionic flavin semiquinone intermediates in oxidative catalysis”. Arch. Biochem. Biophys. 493: 53-61. PMID 19577534. 
  4. ↑ Francis, K. and Gadda, G. (2009). „Kinetic evidence for an anion binding pocket in the active site of nitronate monooxygenase”. Bioorg. Chem. 37: 167-172. PMID 19683782. 

Literatura

Vanjske veze