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Nikotin dehidrogenaza
Identifikatori
EC broj	1.5.99.4
CAS broj	37256-31-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Nikotin dehidrogenaza (EC 1.5.99.4, nikotinska oksidaza, D-nikotinska oksidaza, nikotin:(akceptor) 6-oksidoreduktaza (hidroksilacija), L-nikotinska oksidaza) je enzim sa sistematskim imenom nikotin:akceptor 6-oksidoreduktaza (hidroksilacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(S)-nikotin + akceptor + H₂O

\rightleftharpoons

(S)-6-hidroksinikotin + redukovani akceptor

Ovaj enzim je metaloprotein (FMN). On može da deljuje na prirodni (S)-enantiomer i na sintetički (R)-enantiomer nikotina.

Reference

↑ Behrman, E.J. and Stanier, R.Y. (1957). „The bacterial oxidation of nicotinic acid”. J. Biol. Chem. 228: 923-945. PMID 13475371.
↑ Decker, K. and Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta 105: 313-324. PMID 5849820.
↑ Hochstein, L.I. and Dalton, B.P. (1967). „The purification and properties of nicotine oxidase”. Biochim. Biophys. Acta 139: 56-68. PMID 4962139.
↑ Hochstein, L.I. and Rittenberg, S.C. (1959). „The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine”. J. Biol. Chem. 234: 156-160. PMID 13610912.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Nicotine+dehydrogenase

[1] Behrman, E.J. and Stanier, R.Y. (1957). „The bacterial oxidation of nicotinic acid”. J. Biol. Chem. 228: 923-945. PMID 13475371.

[2] Decker, K. and Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta 105: 313-324. PMID 5849820.

[3] Hochstein, L.I. and Dalton, B.P. (1967). „The purification and properties of nicotine oxidase”. Biochim. Biophys. Acta 139: 56-68. PMID 4962139.

[4] Hochstein, L.I. and Rittenberg, S.C. (1959). „The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine”. J. Biol. Chem. 234: 156-160. PMID 13610912.

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