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N2-(2-karboksietil)arginin sintaza
Identifikatori
EC broj	2.5.1.66
CAS broj	250207-48-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

N²-(2-karboksietil)arginin sintaza (EC 2.5.1.66, CEAS, N²-(2-karboksietil)arginin sintetaza, CEA sintetaza, gliceraldehid-3-fosfat:L-arginin 2-N-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil)) je enzim sa sistematskim imenom gliceraldehid-3-fosfat:L-arginin N²-(2-hidroksi-3-oksopropil) transferaza (formira 2-karboksietil).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-gliceraldehid 3-fosfat + L-arginin

\rightleftharpoons

N²-(2-karboksietil)-L-arginin + fosfat

Za dejstvo ovog enzima je neophodan tiamin difosfat. On katalizuje prvi korak u biosintezi klavulanske kiseline.

Reference

↑ Caines, M.E.C., Elkins, J.M., Hewitson, K.S. and Schofield, C.J. (2004). „Crystal structure and mechanistic implications of N²-(2-carboxyethyl)arginine synthase, the first enzymes in the clavulanic acid biosynthesis pathway”. J. Biol. Chem. 279: 5685-5692. PMID 14623876.
↑ Khaleeli, N., Li, R. and Townsend, C.A. (1999). „Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction”. J. Am. Chem. Soc. 121: 9223-9224.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH N2-(2-carboxyethyl)arginine+synthase

[1] Caines, M.E.C., Elkins, J.M., Hewitson, K.S. and Schofield, C.J. (2004). „Crystal structure and mechanistic implications of N²-(2-carboxyethyl)arginine synthase, the first enzymes in the clavulanic acid biosynthesis pathway”. J. Biol. Chem. 279: 5685-5692. PMID 14623876.

[2] Khaleeli, N., Li, R. and Townsend, C.A. (1999). „Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction”. J. Am. Chem. Soc. 121: 9223-9224.

[1]

[2]

N2-(2-karboksietil)arginin sintaza

Reference

Literatura

Vanjske veze