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N,N'-diacetilegionaminat sintaza
Identifikatori
EC broj	2.5.1.101
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

N,N'-diacetilegionaminat sintaza (EC 2.5.1.101, neuB (gen), legI (gen)) je enzim sa sistematskim imenom fosfenolpiruvat:2,4-diacetamido-2,4,6-tridezoksi-alfa-D-mannopiranoza 1-(2-karboksi-2-oksoetil)transferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2,4-diacetamido-2,4,6-tridezoksi-alfa-D-manopiranoza + fosfenolpiruvat + H₂O

\rightleftharpoons

N,N'-diacetillegionaminat + fosfat

Za dejstvo ovog enzima je neophodan divalentni metalni jon, poput Mn²⁺. Enzim je izolovan iz bakterija Legionella pneumophila i Campylobacter jejuni, gde učestvuje u biosinteza legionaminske kiseline.

Reference

↑ Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). „Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila”. Biochemistry 47: 3272-3282. PMID 18275154.
↑ Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). „The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors”. Glycobiology 19: 715-725. PMID 19282391.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH N,N'-diacetyllegionaminate+synthase

[1] Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). „Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila”. Biochemistry 47: 3272-3282. PMID 18275154.

[2] Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). „The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors”. Glycobiology 19: 715-725. PMID 19282391.

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