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Metionin-tRNK ligaza
	Metionin-tRNK ligaza monomer, Human
Identifikatori
EC broj	6.1.1.10
CAS broj	9033-22-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Metionin-tRNK ligaza (EC 6.1.1.10, metionil-tRNK sintetaza, metionil-transferna ribonukleinsko kiselinska sintetaza, metionil-transferna ribonukleatna sintetaza, metionil-transferna RNK sintetaza, metioninska translaza, MetRS) je enzim sa sistematskim imenom L-metionin:tRNKMet ligaza (formira AMP).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-metionin + tRNK^Met

\rightleftharpoons

AMP + difosfat + L-metionil-tRNK^Met

U organizmima koji formiraju N-formilmetionil-tRNKfMet za inicijaciju translacije, ovaj enzim takođe prepoznaje initiator tRNKfMet i katalizuje formiranje L-metionil-tRNKfMet.

Reference

↑ Bergmann, F.H., Berg, P. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli”. J. Biol. Chem. 236: 1735-1740.
↑ Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L. (1992). „Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase”. Proc. Natl. Acad. Sci. USA 89: 9262-9266. PMID 1409632.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Methionine---tRNA+ligase

[1] Bergmann, F.H., Berg, P. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli”. J. Biol. Chem. 236: 1735-1740.

[2] Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L. (1992). „Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase”. Proc. Natl. Acad. Sci. USA 89: 9262-9266. PMID 1409632.

[1]

[2]