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Metilkgonon reduktaza
Identifikatori
EC broj	1.1.1.334
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Metilkgonon reduktaza (EC 1.1.1.334, MecgoR (gen)) je enzim sa sistematskim imenom ekgonin metil ester:NADP⁺ oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

ekgonin metil estar + NADP⁺

\rightleftharpoons

ekgonon metil estar + NADPH + H⁺

Ovaj enzim iz biljke Eritroksilum coca katalizuje predzadnji korak biosinteze kokaina. In vivo reakcija teče u suprotnom smeru. Sa NADH umesto NADPH brzina reakcije je redukovana do 14%. Ovaj enzim takođe redukuje tropinon, nortropinon i 6-hidroksitropinon, ali sa nižim reakcionim brzinama.

Reference

↑ Jirschitzka, J., Schmidt, G.W., Reichelt, M., Schneider, B., Gershenzon, J. and D'Auria, J.C. (2012). „Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae”. Proc. Natl. Acad. Sci. USA 109: 10304-10309. PMID 22665766.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Methylecgonone+reductase

[1] Jirschitzka, J., Schmidt, G.W., Reichelt, M., Schneider, B., Gershenzon, J. and D'Auria, J.C. (2012). „Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae”. Proc. Natl. Acad. Sci. USA 109: 10304-10309. PMID 22665766.

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