Makrofagna elastaza

Makrofagna elastaza
Identifikatori
EC broj 3.4.24.65
CAS broj 2594837
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Makrofagna elastaza (EC 3.4.24.65, metaloelastaza, ljudska makrofagna metaloelastaza (HME)) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza rastvornog i nerastvornog elastina. Do specifičnog razlaganja takođe dolazi u Ala14-Leu- i -Tyr16-Leu- u B lancu insulina

Ovaj enzim se formira iz proenzima sa masom od 53 kDa.

Reference

  1. ↑ Banda, M.J. and Werb, Z. (1981). „Mouse macrophage elastase. Purification and characterization as a metalloproteinase”. Biochem. J. 193: 589-605. PMID 7030312. 
  2. ↑ Kettner, C., Shaw, E., White, R. and Janoff, A. (1981). „The specificity of macrophage elastase on the insulin B-chain”. Biochem. J. 195: 369-372. PMID 7032505. 
  3. ↑ Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M. and Ley, T.J. (1992). „Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase”. J. Biol. Chem. 267: 4664-4671. PMID 1537850. 
  4. ↑ Shapiro, S.D., Kobayashi, D.K. and Ley, T.J. (1993). „Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages”. J. Biol. Chem. 268: 23824-23829. PMID 8226919. 

Literatura

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