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Lupeolna sintaza
Identifikatori
EC broj	5.4.99.41
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Lupeolna sintaza (EC 5.4.99.41, LUPI, BPW, RcLUS) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen mutaza (ciklizacija, formira lupeol).^[1]^[2]^[3]^[4]^[5]^[6]^[7] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3S)-2,3-epoksi-2,3-dihidroskvalen

\rightleftharpoons

lupeol

Ovaj enzim takođe forms pojedine beta-amirine.

Reference

↑ Herrera, J.B., Bartel, B., Wilson, W.K. and Matsuda, S.P. (1998). „Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene”. Phytochemistry 49: 1905-1911. PMID 9883589.
↑ Shibuya, M., Zhang, H., Endo, A., Shishikura, K., Kushiro, T. and Ebizuka, Y. (1999). „Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases”. Eur. J. Biochem. 266: 302-307. PMID 10542078.
↑ Segura, M.J., Meyer, M.M. and Matsuda, S.P. (2000). „Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol”. Org. Lett. 2: 2257-2259. PMID 10930257.
↑ Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). „Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants”. Biol. Pharm. Bull. 26: 642-650. PMID 12736505.
↑ Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). „Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra”. Biol. Pharm. Bull. 27: 1086-1092. PMID 15256745.
↑ Guhling, O., Hobl, B., Yeats, T. and Jetter, R. (2006). „Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis”. Arch. Biochem. Biophys. 448: 60-72. PMID 16445885.
↑ Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). „Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae”. FEBS J. 274: 5028-5042. PMID 17803686.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Lupeol+synthase

[1] Herrera, J.B., Bartel, B., Wilson, W.K. and Matsuda, S.P. (1998). „Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene”. Phytochemistry 49: 1905-1911. PMID 9883589.

[2] Shibuya, M., Zhang, H., Endo, A., Shishikura, K., Kushiro, T. and Ebizuka, Y. (1999). „Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases”. Eur. J. Biochem. 266: 302-307. PMID 10542078.

[3] Segura, M.J., Meyer, M.M. and Matsuda, S.P. (2000). „Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol”. Org. Lett. 2: 2257-2259. PMID 10930257.

[4] Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). „Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants”. Biol. Pharm. Bull. 26: 642-650. PMID 12736505.

[5] Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). „Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra”. Biol. Pharm. Bull. 27: 1086-1092. PMID 15256745.

[6] Guhling, O., Hobl, B., Yeats, T. and Jetter, R. (2006). „Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis”. Arch. Biochem. Biophys. 448: 60-72. PMID 16445885.

[7] Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). „Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae”. FEBS J. 274: 5028-5042. PMID 17803686.

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